DLG2, discs large MAGUK scaffold protein 2, 1740

N. diseases: 44; N. variants: 28
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs683250
rs683250
Entrez Id: 1740;107984425
Gene Symbol: DLG2;LOC107984425
DLG2;LOC107984425
CUI: C0038436
Disease:
Post-Traumatic Stress Disorder 		0.010 GeneticVariation BEFREE Further, by conditioning on brain volume GWAS, we identified novel variants that associate with smaller brain volumes and increase risk for disorders: rs56242606 was found to increase risk for anxiety disorders, while two variants (rs6470292 and rs683250) increase risk for PTSD, when conditioning on the GWAS of putamen volume. 30699873 2019
dbSNP: rs683250
rs683250
Entrez Id: 1740;107984425
Gene Symbol: DLG2;LOC107984425
DLG2;LOC107984425
CUI: C0003469
Disease:
Anxiety Disorders 		0.010 GeneticVariation BEFREE Further, by conditioning on brain volume GWAS, we identified novel variants that associate with smaller brain volumes and increase risk for disorders: rs56242606 was found to increase risk for anxiety disorders, while two variants (rs6470292 and rs683250) increase risk for PTSD, when conditioning on the GWAS of putamen volume. 30699873 2019
dbSNP: rs1155311
rs1155311
Entrez Id: 1740
Gene Symbol: DLG2
DLG2
CUI: C0007222
Disease:
Cardiovascular Diseases 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs11823251
rs11823251
Entrez Id: 1740
Gene Symbol: DLG2
DLG2
CUI: C1314691
Disease:
Age at menarche 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs349071
rs349071
Entrez Id: 1740
Gene Symbol: DLG2
DLG2
CUI: C1305855
Disease:
Body mass index 		0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
dbSNP: rs1864774
rs1864774
Entrez Id: 1740
Gene Symbol: DLG2
DLG2
CUI: C0036341
Disease:
Schizophrenia 		C 0.700 GeneticVariation GWASCAT Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect. 30285260 2019
dbSNP: rs349071
rs349071
Entrez Id: 1740
Gene Symbol: DLG2
DLG2
CUI: C1305855
Disease:
Body mass index 		A 0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. 30239722 2019
dbSNP: rs349088
rs349088
Entrez Id: 1740
Gene Symbol: DLG2
DLG2
CUI: C1305855
Disease:
Body mass index 		A 0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. 30239722 2019
dbSNP: rs536665
rs536665
Entrez Id: 1740
Gene Symbol: DLG2
DLG2
CUI: C0205682
Disease:
Waist-Hip Ratio 		A 0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry. 30239722 2019
dbSNP: rs117214796
rs117214796
Entrez Id: 1740
Gene Symbol: DLG2
DLG2
CUI: C0003873
Disease:
Rheumatoid Arthritis 		0.700 GeneticVariation GWASCAT Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis. 30166627 2018
dbSNP: rs116875887
rs116875887
Entrez Id: 1740
Gene Symbol: DLG2
DLG2
CUI: C0596887
Disease:
mathematical ability 		C 0.700 GeneticVariation GWASCAT Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. 30038396 2018
dbSNP: rs1532312
rs1532312
Entrez Id: 1740
Gene Symbol: DLG2
DLG2
CUI: C0596887
Disease:
mathematical ability 		T 0.700 GeneticVariation GWASCAT Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. 30038396 2018
dbSNP: rs74443493
rs74443493
Entrez Id: 1740
Gene Symbol: DLG2
DLG2
CUI: C0596887
Disease:
mathematical ability 		A 0.700 GeneticVariation GWASCAT Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. 30038396 2018
dbSNP: rs77300868
rs77300868
Entrez Id: 1740
Gene Symbol: DLG2
DLG2
CUI: C0596887
Disease:
mathematical ability 		A 0.700 GeneticVariation GWASCAT Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. 30038396 2018
dbSNP: rs10466716
rs10466716
Entrez Id: 1740;101929043
Gene Symbol: DLG2;DLG2-AS2
DLG2;DLG2-AS2
CUI: C0410702
Disease:
Adolescent idiopathic scoliosis 		0.700 GeneticVariation GWASCAT The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease. 30019117 2018
dbSNP: rs10466716
rs10466716
Entrez Id: 1740;101929043
Gene Symbol: DLG2;DLG2-AS2
DLG2;DLG2-AS2
CUI: C1837461
Disease:
SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3 		0.700 GeneticVariation GWASCAT The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease. 30019117 2018
dbSNP: rs11233632
rs11233632
Entrez Id: 1740
Gene Symbol: DLG2
DLG2
CUI: C0036341
Disease:
Schizophrenia 		0.010 GeneticVariation BEFREE Based on conjunctional FDR < 0.05, we identified 2 loci shared between SCZ and ICV implicating genes FOXO3 (rs10457180) and ITIH4 (rs4687658), 2 loci shared between SCZ and hippocampal volume implicating SLC4A10 (rs4664442) and SPATS2L (rs1653290), and 2 loci shared between SCZ and volume of putamen implicating DCC (rs4632195) and DLG2 (rs11233632). 29136250 2018
dbSNP: rs1864774
rs1864774
Entrez Id: 1740
Gene Symbol: DLG2
DLG2
CUI: C0036341
Disease:
Schizophrenia 		C 0.700 GeneticVariation GWASCAT Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia. 28991256 2017
dbSNP: rs790357
rs790357
Entrez Id: 1740
Gene Symbol: DLG2
DLG2
CUI: C0595921
Disease:
Intraocular pressure disorder 		0.010 GeneticVariation BEFREE The GWAS results revealed a study-wise significant association for IOP at rs790357, which is located within <i>DLG2</i> on chr11q14.1 (p = 1.02×10<sup>-7</sup>). 28966548 2017
dbSNP: rs655484
rs655484
Entrez Id: 1740
Gene Symbol: DLG2
DLG2
CUI: C0338480
Disease:
Common Migraine 		C 0.700 GeneticVariation GWASCAT Genome-wide association study identifies novel susceptibility loci for migraine in Han Chinese resided in Taiwan. 28952330 2018
dbSNP: rs3793947
rs3793947
Entrez Id: 1740
Gene Symbol: DLG2
DLG2
CUI: C0030567
Disease:
Parkinson Disease 		G 0.700 GeneticVariation GWASCAT A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci. 28892059 2017
dbSNP: rs142615018
rs142615018
Entrez Id: 1740
Gene Symbol: DLG2
DLG2
CUI: C1305855
Disease:
Body mass index 		T 0.700 GeneticVariation GWASCAT Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits. 28552196 2017
dbSNP: rs286028
rs286028
Entrez Id: 1740
Gene Symbol: DLG2
DLG2
CUI: C0005910
Disease:
Body Weight 		A 0.700 GeneticVariation GWASCAT Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits. 28552196 2017
dbSNP: rs7479949
rs7479949
Entrez Id: 1740
Gene Symbol: DLG2
DLG2
CUI: C0030567
Disease:
Parkinson Disease 		0.700 GeneticVariation GWASCAT Genome-wide association study of Parkinson's disease in East Asians. 28011712 2017
dbSNP: rs2155413
rs2155413
Entrez Id: 1740
Gene Symbol: DLG2
DLG2
CUI: C0027092
Disease:
Myopia 		0.700 GeneticVariation GWASCAT Detection and interpretation of shared genetic influences on 42 human traits. 27182965 2016